The Pamlico Sound is a lagoon or sound located off of the Atlantic coast of North Carolina. It is separated from the Atlantic Ocean by barrier islands such as Cape Hatteras. Pamlico Sound is the second largest estuary in the United States after Chesapeake Bay. It is located at the mouth of the Pamlico and Neuse rivers. Explorer Giovanni da Verrazzano mistook the sound for the Pacific Ocean.


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